In a multicenter, open-label, randomized controlled trial we aim to demonstrate that an early switch from intravenous to oral antimicrobial therapy is non-inferior to a conventional days course of intravenous therapy regarding efficacy and safety.Īn early switch from intravenous to oral therapy would provide several benefits such as earlier discharge, fewer adverse reactions associated with intravenous therapy, increased quality of life, and cost savings.
#PDPLAYER STITCHING FULL#
However, there is insufficient evidence that a full course of intravenous antibiotic therapy is always required in patients with a low risk of SAB-related complications. This relatively long course serves to prevent SAB-related complications such as endocarditis and vertebral osteomyelitis that may result from hematogenous dissemination to distant sites. A course of at least 14 days of intravenous antimicrobials is considered standard therapy in "uncomplicated" SAB. Staphylococcus aureus bloodstream infection SAB is a common disease with aboutcases occurring annually in Europe. This threat underscores the need to maximize clinical utility of existing antibiotics, through more rational prescription, e. Increasing resistance to antibiotic agents has been recognized as a major health problem worldwide that will even aggravate due to the lack of new antimicrobial agents within the next decade. Study record managers: refer to the Data Element Definitions if submitting registration or results information.